As the Premier League resumes, Arteta manages his 300th game at Arsenal; Enzo Maresca and Arne Slot face pressure, and Nuno Espírito Santo aims to redefine West Ham. Full fixtures, key matchups, and predictions.

Key Fixtures (October 3–5, 2025)

Arsenal vs West Ham — Saturday, October 4, 2025

Chelsea vs Liverpool — Saturday, October 4, 2025

Manchester United vs Sunderland — Saturday, October 4, 2025

Leeds United vs Tottenham Hotspur — Saturday, October 4, 2025

Other marquee games: Wolves vs Brighton & Everton vs Crystal Palace

Storylines & Coaches Under the Microscope

Arsenal vs West Ham — Arteta’s 300th Match

Mikel Arteta is managing his 300th game in charge of Arsenal. He holds a 58% win rate, the highest among Arsenal coaches who have overseen more than 50 matches.

 

West Ham’s boss Nuno Espírito Santo, newly appointed after Graham Potter’s dismissal, has stressed that building an identity and culture at the club is his priority.

Chelsea vs Liverpool — Maresca vs Slot

Enzo Maresca has acknowledged Chelsea’s recent inconsistency but believes they can compete, especially given injuries within the Liverpool squad.

Arne Slot, Liverpool’s head coach, confirmed in his press conferences that captain Alisson will be out until after the international break with a hamstring injury, making the game even more challenging for the Reds.

Manchester United vs Sunderland — Amorim Under Pressure

Rúben Amorim remains Manchester United’s head coach (appointed November 1, 2024, contract until 2027).

United are rumored to be monitoring possible successors, including Oliver Glasner (Crystal Palace), Andoni Iraola, and Michael Carrick for caretaker setups.

Other Undercurrents

Injury Watch: Liverpool’s Alisson will miss upcoming matches; Chelsea have defensive absences.

Motivation Points: Arteta’s landmark, West Ham’s new direction, United’s urgent need for results, Spurs vs Leeds midfield battle, etc.

Predictions Table

Match Likely Outcome

Arsenal vs West Ham Narrow Arsenal win  home advantage + Arteta boost.

Chelsea vs Liverpool Draw or slim Liverpool edge even without Alisson.

Manchester United vs Sunderland United must win  pressure is too high to slip.

Leeds United vs Tottenham Spurs to edge it if they start aggressively.

Final Word

This weekend’s fixtures aren’t just about three points they’re about momentum, identity, and belief. Coaches are under pressure; fans are waiting for signs. Will victories quiet the critics or will cracks get louder?